High resolution crystal structure of a KRAS promoter G-quadruplex reveals a dimer with extensive poly-A π-stacking interactions for small-molecule recognition

Aberrant KRAS signaling is a driver of many cancers and yet remains an elusive target for drug therapy. The nuclease hypersensitive element of the KRAS promoter has been reported to form secondary DNA structures called G-quadruplexes (G4s) which may play important roles in regulating KRAS expression...

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Detalles Bibliográficos
Autores principales: Ou, Arnold, Schmidberger, Jason W, Wilson, Katie A, Evans, Cameron W, Hargreaves, Jessica A, Grigg, Melanie, O’Mara, Megan L, Iyer, K Swaminathan, Bond, Charles S, Smith, Nicole M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7261167/
https://www.ncbi.nlm.nih.gov/pubmed/32313953
http://dx.doi.org/10.1093/nar/gkaa262

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7261167/
https://www.ncbi.nlm.nih.gov/pubmed/32313953
http://dx.doi.org/10.1093/nar/gkaa262

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