Cargando…

Inhibition of P2X7 Purinergic Receptor Ameliorates Cardiac Fibrosis by Suppressing NLRP3/IL-1β Pathway

P2X7 purinergic receptor (P2X7R) has been implicated in several cardiovascular diseases. However, whether it regulates cardiac fibrosis remains elusive. Herein, its involvement in the development of cardiac fibrosis was examined using a transverse aortic constriction (TAC) mice model and cardiac fib...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhou, Junteng, Tian, Geer, Quan, Yue, Li, Junli, Wang, Xiaojiao, Wu, Wenchao, Li, Miaoling, Liu, Xiaojing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7261319/ https://www.ncbi.nlm.nih.gov/pubmed/32566102 http://dx.doi.org/10.1155/2020/7956274

Ejemplares similares

Purinergic P2 Receptors: Novel Mediators of Mechanotransduction
por: Kong, Qihang, et al.
Publicado: (2021)

Inhibition of P2X7 Purinergic Receptor Ameliorates Fibromyalgia Syndrome by Suppressing NLRP3 Pathway
por: D’Amico, Ramona, et al.
Publicado: (2021)

Voltage-dependent anion channel 1 (VDAC1) overexpression alleviates cardiac fibroblast activation in cardiac fibrosis via regulating fatty acid metabolism
por: Tian, Geer, et al.
Publicado: (2023)

The long noncoding RNA THBS1-AS1 promotes cardiac fibroblast activation in cardiac fibrosis by regulating TGFBR1
por: Zhou, Junteng, et al.
Publicado: (2023)

Identification of circular RNAs in cardiac hypertrophy and cardiac fibrosis
por: Chen, Yan, et al.
Publicado: (2022)

P2Y1 Receptor Agonist Attenuates Cardiac Fibroblasts Activation Triggered by TGF-β1
por: Tian, Geer, et al.
Publicado: (2021)

Stimulation of Sigma-1 Receptor Protects against Cardiac Fibrosis by Alleviating IRE1 Pathway and Autophagy Impairment
por: Qu, Jing, et al.
Publicado: (2021)

Aerobic Exercise Ameliorates Myocardial Inflammation, Fibrosis and Apoptosis in High-Fat-Diet Rats by Inhibiting P2X7 Purinergic Receptors
por: Chen, Xudong, et al.
Publicado: (2019)

Purinergic P2X7 receptor antagonist ameliorates intestinal inflammation in postoperative ileus
por: KIMURA, Hitomi, et al.
Publicado: (2022)

Purinergic P2X7 Receptor Mediates the Elimination of Trichinella spiralis by Activating NF-κB/NLRP3/IL-1β Pathway in Macrophages
por: Guan, Fei, et al.
Publicado: (2021)

The Purinergic P2X7 Receptor-NLRP3 Inflammasome Pathway: A New Target in Alcoholic Liver Disease?
por: Le Daré, Brendan, et al.
Publicado: (2021)

Purinergic 2X7 receptor is involved in adipogenesis and lipid degradation
por: Li, Jing, et al.
Publicado: (2022)

The role of the purinergic P2X(7 )receptor in inflammation
por: Lister, Martin F, et al.
Publicado: (2007)

Mitochondrial ROS-Modulated mtDNA: A Potential Target for Cardiac Aging
por: Quan, Yue, et al.
Publicado: (2020)

Salidroside Ameliorates Depression by Suppressing NLRP3-Mediated Pyroptosis via P2X7/NF-κB/NLRP3 Signaling Pathway
por: Chai, Yuhui, et al.
Publicado: (2022)

P2X7 Receptor–Mediated Inflammation in Cardiovascular Disease
por: Zhou, Junteng, et al.
Publicado: (2021)

Deficiency of the Purinergic Receptor 2X(7) Attenuates Nonalcoholic Steatohepatitis Induced by High-Fat Diet: Possible Role of the NLRP3 Inflammasome
por: Blasetti Fantauzzi, Claudia, et al.
Publicado: (2017)

The purinergic receptor P2X7 and the NLRP3 inflammasome are druggable host factors required for SARS-CoV-2 infection
por: Lécuyer, Déborah, et al.
Publicado: (2023)

ATP release and purinergic signaling in NLRP3 inflammasome activation
por: Gombault, Aurélie, et al.
Publicado: (2013)

Mitochondrial Localization and Function of the Purinergic Receptor P2X(7)
por: Kroemer, Guido, et al.
Publicado: (2021)

The P2X7 purinergic receptor in intervertebral disc degeneration
por: Penolazzi, Letizia, et al.
Publicado: (2021)

Chlamydia evasion of neutrophil host defense results in NLRP3 dependent myeloid-mediated sterile inflammation through the purinergic P2X7 receptor
por: Yang, Chunfu, et al.
Publicado: (2021)

Interaction of Purinergic P2X4 and P2X7 Receptor Subunits
por: Schneider, Markus, et al.
Publicado: (2017)

Associations Between the Purinergic Receptor P2X7 and Leprosy Disease
por: Souza, Rebeka da Conceição, et al.
Publicado: (2021)

NecroX-5 ameliorates bleomycin-induced pulmonary fibrosis via inhibiting NLRP3-mediated epithelial–mesenchymal transition
por: Min, Li, et al.
Publicado: (2022)

Suppression of NLRP3 Inflammasome Activation Ameliorates Chronic Kidney Disease-Induced Cardiac Fibrosis and Diastolic Dysfunction
por: Bugyei-Twum, Antoinette, et al.
Publicado: (2016)

Lack of the purinergic receptor P2X(7) results in resistance to contact hypersensitivity
por: Weber, Felix C., et al.
Publicado: (2010)

Special Issue for Purinergic Receptors, Particularly P2X(7) Receptor, in the Eye
por: Sugiyama, Tetsuya
Publicado: (2018)

Understanding the Role of Purinergic P2X7 Receptors in the Gastrointestinal System: A Systematic Review
por: Cheng, Nathalie, et al.
Publicado: (2021)

Naofucong Ameliorates High Glucose Induced Hippocampal Neuron Injury Through Suppressing P2X7/NLRP1/Caspase-1 Pathway
por: Jing, Guangchan, et al.
Publicado: (2021)

Divalent metal modulation of Japanese flounder (Paralichthys olivaceus) purinergic P2X7 receptor
por: Paredes, Carolina, et al.
Publicado: (2018)

The Role of Bile Acids in Cardiovascular Diseases: from Mechanisms to Clinical Implications
por: Zhang, Shuwen, et al.
Publicado: (2023)

Evidence for associations between the purinergic receptor P2X(7) (P2RX7) and toxoplasmosis
por: Jamieson, Sarra E., et al.
Publicado: (2010)

P2X7 Receptor and Purinergic Signaling: Orchestrating Mitochondrial Dysfunction in Neurodegenerative Diseases
por: Zelentsova, Alexsandra S., et al.
Publicado: (2022)

Danggui Buxue Tang Ameliorates Bleomycin-Induced Pulmonary Fibrosis by Suppressing the TLR4/NLRP3 Signaling Pathway in Rats
por: Wang, Jiepeng, et al.
Publicado: (2021)

Curcumin Ameliorates Diabetic Nephropathy by Suppressing NLRP3 Inflammasome Signaling
por: Lu, Miaomiao, et al.
Publicado: (2017)

Purinergic signalling in autoimmunity: A role for the P2X7R in systemic lupus erythematosus?
por: Di Virgilio, Francesco, et al.
Publicado: (2016)

Contraction of intestinal effector T cells by retinoic acid-induced purinergic receptor P2X7
por: Hashimoto-Hill, S., et al.
Publicado: (2016)

A Possible Causal Involvement of Neuroinflammatory, Purinergic P2X7 Receptors in Psychiatric Disorders
por: Zhang, Ying, et al.
Publicado: (2022)

Purinergic neurotransmission receptor P2X4 silencing alleviates intracerebral hemorrhage-induced neuroinflammation by blocking the NLRP1/Caspase-1 pathway
por: Wu, Yuanshui, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_c69qldptn0ci9l1mbbmhl8j20u