E3 ligase Herc4 regulates Hedgehog signalling through promoting Smoothened degradation

Hedgehog (Hh) signalling plays conserved roles in controlling embryonic development; its dysregulation causes many diseases including cancers. The G protein-coupled receptor Smoothened (Smo) is the key signal transducer of the Hh pathway, whose posttranslational regulation has been shown to be criti...

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Detalles Bibliográficos
Autores principales: Jiang, Weirong, Yao, Xia, Shan, Zhaoliang, Li, Wenting, Gao, Yuxue, Zhang, Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7261483/
https://www.ncbi.nlm.nih.gov/pubmed/30925584
http://dx.doi.org/10.1093/jmcb/mjz024

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7261483/
https://www.ncbi.nlm.nih.gov/pubmed/30925584
http://dx.doi.org/10.1093/jmcb/mjz024

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