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E3 ligase Herc4 regulates Hedgehog signalling through promoting Smoothened degradation
Hedgehog (Hh) signalling plays conserved roles in controlling embryonic development; its dysregulation causes many diseases including cancers. The G protein-coupled receptor Smoothened (Smo) is the key signal transducer of the Hh pathway, whose posttranslational regulation has been shown to be criti...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7261483/ https://www.ncbi.nlm.nih.gov/pubmed/30925584 http://dx.doi.org/10.1093/jmcb/mjz024 |