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Cellular phosphatidic acid sensor, α-synuclein N-terminal domain, detects endogenous phosphatidic acid in macrophagic phagosomes and neuronal growth cones

Phosphatidic acid (PA) is the simplest phospholipid and is involved in the regulation of various cellular events. Recently, we developed a new PA sensor, the N-terminal region of α-synuclein (α-Syn-N). However, whether α-Syn-N can sense physiologically produced, endogenous PA remains unclear. We fir...

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Detalles Bibliográficos
Autores principales: Yamada, Haruka, Hoshino, Fumi, Lu, Qiang, Sakane, Fumio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7261706/
https://www.ncbi.nlm.nih.gov/pubmed/32490215
http://dx.doi.org/10.1016/j.bbrep.2020.100769