Modelling Age-Related Changes in the Pharmacokinetics of Risperidone and 9-Hydroxyrisperidone in Different CYP2D6 Phenotypes Using a Physiologically Based Pharmacokinetic Approach

PURPOSE: Dose-optimization strategies for risperidone are gaining in importance, especially in the elderly. Based on the genetic polymorphism of cytochrome P 450 (CYP) 2D6 genetically and age-related changes cause differences in the pharmacokinetics of risperidone and 9-hydroxyrisperidone. The goal...

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Detalles Bibliográficos
Autores principales: Kneller, Lisa Alina, Hempel, Georg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7261739/
https://www.ncbi.nlm.nih.gov/pubmed/32476097
http://dx.doi.org/10.1007/s11095-020-02843-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7261739/
https://www.ncbi.nlm.nih.gov/pubmed/32476097
http://dx.doi.org/10.1007/s11095-020-02843-7

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