Cargando…

Efficacy of an Inhibitor of Hepatitis B Virus Expression in Combination With Entecavir and Interferon‐α in Woodchucks Chronically Infected With Woodchuck Hepatitis Virus

RG7834 is a small‐molecule inhibitor of hepatitis B virus (HBV) gene expression that significantly reduces the levels of hepatitis B surface antigen (HBsAg) and HBV DNA in a humanized liver HBV mouse model. In the current study, we evaluated the potency of RG7834 in the woodchuck model of chronic HB...

Descripción completa

Detalles Bibliográficos
Autores principales:	Menne, Stephan, Wildum, Steffen, Steiner, Guido, Suresh, Manasa, Korolowicz, Kyle, Balarezo, Maria, Yon, Changsuek, Murreddu, Marta, Hong, Xupeng, Kallakury, Bhaskar V., Tucker, Robin, Yang, Song, Young, John A.T., Javanbakht, Hassan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262289/ https://www.ncbi.nlm.nih.gov/pubmed/32490326 http://dx.doi.org/10.1002/hep4.1502

Ejemplares similares

Combination Treatment with the Vimentin-Targeting Antibody hzVSF and Tenofovir Suppresses Woodchuck Hepatitis Virus Infection in Woodchucks
por: Korolowicz, Kyle E., et al.
Publicado: (2021)

Treatment with the Immunomodulator AIC649 in Combination with Entecavir Produces Antiviral Efficacy in the Woodchuck Model of Chronic Hepatitis B
por: Korolowicz, Kyle E., et al.
Publicado: (2021)

Innate and adaptive immunity associated with resolution of acute woodchuck hepatitis virus infection in adult woodchucks
por: Suresh, Manasa, et al.
Publicado: (2019)

Antiviral Efficacy and Host Immune Response Induction during Sequential Treatment with SB 9200 Followed by Entecavir in Woodchucks
por: Suresh, Manasa, et al.
Publicado: (2017)

Toll-Like Receptor 7 Agonist RG7854 Mediates Therapeutic Efficacy and Seroconversion in Woodchucks With Chronic Hepatitis B
por: Wildum, Steffen, et al.
Publicado: (2022)

Liver‐Targeted Toll‐Like Receptor 7 Agonist Combined With Entecavir Promotes a Functional Cure in the Woodchuck Model of Hepatitis B Virus
por: Korolowizc, Kyle E., et al.
Publicado: (2019)

Involvement of Innate Immune Receptors in the Resolution of Acute Hepatitis B in Woodchucks
por: Suresh, Manasa, et al.
Publicado: (2021)

Application of the woodchuck animal model for the treatment of hepatitis B virus-induced liver cancer
por: Suresh, Manasa, et al.
Publicado: (2021)

Recent Drug Development in the Woodchuck Model of Chronic Hepatitis B
por: Suresh, Manasa, et al.
Publicado: (2022)

Agonistic Activation of Cytosolic DNA Sensing Receptors in Woodchuck Hepatocyte Cultures and Liver for Inducing Antiviral Effects
por: Suresh, Manasa, et al.
Publicado: (2021)

Antiviral Efficacy and Host Innate Immunity Associated with SB 9200 Treatment in the Woodchuck Model of Chronic Hepatitis B
por: Korolowicz, Kyle E., et al.
Publicado: (2016)

Molecular characterization of woodchuck IFI16 and AIM2 and their expression in woodchucks infected with woodchuck hepatitis virus (WHV)
por: Yan, Qi, et al.
Publicado: (2016)

Enzyme‐altered Liver Cell Foci in Woodchucks Infected with Woodchuck Hepatitis Virus
por: Abe, Kenji, et al.
Publicado: (1988)

Suitability of the woodchuck HCC as a preclinical model for evaluation of intra‐arterial therapies
por: Kim, Alexander Y., et al.
Publicado: (2020)

Cryo-EM structures of human hepatitis B and woodchuck hepatitis virus small spherical subviral particles
por: Liu, Haitao, et al.
Publicado: (2022)

Persistence of the Recombinant Genomes of Woodchuck Hepatitis Virus in the Mouse Model
por: Pan, Danzhen, et al.
Publicado: (2015)

Correction: Intrahepatic Transcriptional Signature Associated with Response to Interferon-α Treatment in the Woodchuck Model of Chronic Hepatitis B
por: Fletcher, Simon P., et al.
Publicado: (2016)

Toll‐Like Receptor 8 Agonist GS‐9688 Induces Sustained Efficacy in the Woodchuck Model of Chronic Hepatitis B
por: Daffis, Stephane, et al.
Publicado: (2020)

Intrahepatic Transcriptional Signature Associated with Response to Interferon-α Treatment in the Woodchuck Model of Chronic Hepatitis B
por: Fletcher, Simon P., et al.
Publicado: (2015)

Combination of DNA Prime – Adenovirus Boost Immunization with Entecavir Elicits Sustained Control of Chronic Hepatitis B in the Woodchuck Model
por: Kosinska, Anna D., et al.
Publicado: (2013)

Therapeutic Vaccination in Chronic Hepatitis B: Preclinical Studies in the Woodchuck
por: Kosinska, Anna D., et al.
Publicado: (2010)

Imaging, Pathology, and Immune Correlates in the Woodchuck Hepatic Tumor Model
por: Mauda-Havakuk, Michal, et al.
Publicado: (2021)

Asymptomatic Hepadnaviral Persistence and Its Consequences in the Woodchuck Model of Occult Hepatitis B Virus Infection
por: Mulrooney-Cousins, Patricia M., et al.
Publicado: (2015)

AIC649 Induces a Bi-Phasic Treatment Response in the Woodchuck Model of Chronic Hepatitis B
por: Paulsen, Daniela, et al.
Publicado: (2015)

Disturbances in the Glutathione/Ophthalmate Redox Buffer System in the Woodchuck Model of Hepatitis Virus-Induced Hepatocellular Carcinoma
por: Andres Ibarra, Rafael, et al.
Publicado: (2011)

Therapeutic vaccination and immunomodulation in the treatment of chronic hepatitis B: preclinical studies in the woodchuck
por: Kosinska, Anna D., et al.
Publicado: (2014)

The Genome Sequence of the Eastern Woodchuck (Marmota monax) – A Preclinical Animal Model for Chronic Hepatitis B
por: Alioto, Tyler S., et al.
Publicado: (2019)

The Expression of PD-1 Ligands and Their Involvement in Regulation of T Cell Functions in Acute and Chronic Woodchuck Hepatitis Virus Infection
por: Zhang, Ejuan, et al.
Publicado: (2011)

Diverse Virus and Host-Dependent Mechanisms Influence the Systemic and Intrahepatic Immune Responses in the Woodchuck Model of Hepatitis B
por: Michalak, Tomasz I.
Publicado: (2020)

Immune Effects of Cryoablation in Woodchuck Hepatocellular Carcinoma
por: Mauda-Havakuk, Michal, et al.
Publicado: (2023)

A241 CHARACTERIZING KUPFFER CELL-VIRUS INTERACTIONS IMMEDIATELY FOLLOWING VIRAL INVASION AND IN ACUTE HEPATITIS IN THE WOODCHUCK HEPATITIS VIRUS MODEL OF HEPATITIS B VIRUS INFECTIONS
por: Al-Yasiri, L, et al.
Publicado: (2023)

Inclusion of the Woodchuck Hepatitis Virus Posttranscriptional Regulatory Element Enhances AAV2-Driven Transduction of Mouse and Human Retina
por: Patrício, Maria I., et al.
Publicado: (2017)

Differential Expression of Woodchuck Toll-Like Receptors 1–10 in Distinct Forms of Infection and Stages of Hepatitis in Experimental Hepatitis B Virus Infection
por: Williams, John Bradley, et al.
Publicado: (2018)

Prevention of liver tumor formation in woodchucks with established hepatocellular carcinoma by treatment with cationic liposome-DNA complexes
por: Fairman, Jeffery, et al.
Publicado: (2017)

A novel hepatovirus identified in wild woodchuck Marmota himalayana
por: Yu, Jie-mei, et al.
Publicado: (2016)

Safety and efficacy of anti-PD-L1 therapy in the woodchuck model of HBV infection
por: Balsitis, Scott, et al.
Publicado: (2018)

Enhancing Transgene Expression from Recombinant AAV8 Vectors in Different Tissues Using Woodchuck Hepatitis Virus Post-Transcriptional Regulatory Element
por: Wang, Lizheng, et al.
Publicado: (2016)

Woodchuck Hepatitis Virus Post-Transcriptional Regulation Element (WPRE) Promotes Anti-CD19 BiTE Expression in Expi293 Cells
por: Moazzami, Reza, et al.
Publicado: (2021)

Primary Seronegative but Molecularly Evident Hepadnaviral Infection Engages Liver and Induces Hepatocarcinoma in the Woodchuck Model of Hepatitis B
por: Mulrooney-Cousins, Patricia M., et al.
Publicado: (2014)

Initial sites of hepadnavirus integration into host genome in human hepatocytes and in the woodchuck model of hepatitis B-associated hepatocellular carcinoma
por: Chauhan, R, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_0td8mi47i4pjho10qjjpigab4g