Interferon-γ and voriconazole combined therapy for refractory meningeal coccidioidomycosis in a patient with interferon-γ deficiency

Coccidioides meningitis (CM) is a challenging infection, given the limited penetration to the cerebrospinal fluid of conventional antifungals, resulting in a high risk of recurrence. We present the first case of a successfully treated persistent CM with voriconazole and adjuvant INF-γ 1b.

Detalles Bibliográficos
Autores principales: De la Hoz, Alejandro, Malek, Alexandre, Hasbun, Rodrigo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262437/
https://www.ncbi.nlm.nih.gov/pubmed/32489879
http://dx.doi.org/10.1016/j.idcr.2020.e00835
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author De la Hoz, Alejandro
Malek, Alexandre
Hasbun, Rodrigo
author_facet De la Hoz, Alejandro
Malek, Alexandre
Hasbun, Rodrigo
author_sort De la Hoz, Alejandro
collection PubMed
description Coccidioides meningitis (CM) is a challenging infection, given the limited penetration to the cerebrospinal fluid of conventional antifungals, resulting in a high risk of recurrence. We present the first case of a successfully treated persistent CM with voriconazole and adjuvant INF-γ 1b.
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spelling pubmed-72624372020-06-01 Interferon-γ and voriconazole combined therapy for refractory meningeal coccidioidomycosis in a patient with interferon-γ deficiency De la Hoz, Alejandro Malek, Alexandre Hasbun, Rodrigo IDCases Article Coccidioides meningitis (CM) is a challenging infection, given the limited penetration to the cerebrospinal fluid of conventional antifungals, resulting in a high risk of recurrence. We present the first case of a successfully treated persistent CM with voriconazole and adjuvant INF-γ 1b. Elsevier 2020-05-21 /pmc/articles/PMC7262437/ /pubmed/32489879 http://dx.doi.org/10.1016/j.idcr.2020.e00835 Text en © 2020 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
De la Hoz, Alejandro
Malek, Alexandre
Hasbun, Rodrigo
Interferon-γ and voriconazole combined therapy for refractory meningeal coccidioidomycosis in a patient with interferon-γ deficiency
title Interferon-γ and voriconazole combined therapy for refractory meningeal coccidioidomycosis in a patient with interferon-γ deficiency
title_full Interferon-γ and voriconazole combined therapy for refractory meningeal coccidioidomycosis in a patient with interferon-γ deficiency
title_fullStr Interferon-γ and voriconazole combined therapy for refractory meningeal coccidioidomycosis in a patient with interferon-γ deficiency
title_full_unstemmed Interferon-γ and voriconazole combined therapy for refractory meningeal coccidioidomycosis in a patient with interferon-γ deficiency
title_short Interferon-γ and voriconazole combined therapy for refractory meningeal coccidioidomycosis in a patient with interferon-γ deficiency
title_sort interferon-γ and voriconazole combined therapy for refractory meningeal coccidioidomycosis in a patient with interferon-γ deficiency
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262437/
https://www.ncbi.nlm.nih.gov/pubmed/32489879
http://dx.doi.org/10.1016/j.idcr.2020.e00835
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