Protein kinase CK2 activates Nrf2 via autophagic degradation of Keap1 and activation of AMPK in human cancer cells

Protein kinase CK2 downregulation induces premature senescence in various human cell types via activation of the reactive oxygen species (ROS)–p53–p21(Cip1/WAF1) pathway. The transcription factor “nuclear factor erythroid 2-related factor 2” (Nrf2) plays an important role in maintaining intracellula...

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Detalles Bibliográficos
Autores principales: Jang, Da Eun, Song, Junbin, Park, Jeong-Woo, Yoon, Soo-Hyun, Bae, Young-Seuk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Biochemistry and Molecular Biology 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262510/
https://www.ncbi.nlm.nih.gov/pubmed/32317087
http://dx.doi.org/10.5483/BMBRep.2020.53.5.044

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262510/
https://www.ncbi.nlm.nih.gov/pubmed/32317087
http://dx.doi.org/10.5483/BMBRep.2020.53.5.044

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