Advances in elucidating the function of leucine-rich repeat protein kinase-2 in normal cells and Parkinson's disease

Autosomal dominant missense mutations that hyperactivate the leucine-rich repeat protein kinase-2 (LRRK2) are a common cause of inherited Parkinson's disease and therapeutic efficacy of LRRK2 inhibitors is being tested in clinical trials. In this review, we discuss the nuts and bolts of our cur...

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Detalles Bibliográficos
Autores principales: Taylor, Matthew, Alessi, Dario R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262585/
https://www.ncbi.nlm.nih.gov/pubmed/32036294
http://dx.doi.org/10.1016/j.ceb.2020.01.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262585/
https://www.ncbi.nlm.nih.gov/pubmed/32036294
http://dx.doi.org/10.1016/j.ceb.2020.01.001

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