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Advances in elucidating the function of leucine-rich repeat protein kinase-2 in normal cells and Parkinson's disease
Autosomal dominant missense mutations that hyperactivate the leucine-rich repeat protein kinase-2 (LRRK2) are a common cause of inherited Parkinson's disease and therapeutic efficacy of LRRK2 inhibitors is being tested in clinical trials. In this review, we discuss the nuts and bolts of our cur...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Elsevier
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262585/ https://www.ncbi.nlm.nih.gov/pubmed/32036294 http://dx.doi.org/10.1016/j.ceb.2020.01.001 |