Synthetic Lethality between DNA Polymerase Epsilon and RTEL1 in Metazoan DNA Replication

Genome stability requires coordination of DNA replication origin activation and replication fork progression. RTEL1 is a regulator of homologous recombination (HR) implicated in meiotic cross-over control and DNA repair in C. elegans. Through a genome-wide synthetic lethal screen, we uncovered an es...

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Detalles Bibliográficos
Autores principales: Bellelli, Roberto, Youds, Jillian, Borel, Valerie, Svendsen, Jennifer, Pavicic-Kaltenbrunner, Visnja, Boulton, Simon J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262601/
https://www.ncbi.nlm.nih.gov/pubmed/32460026
http://dx.doi.org/10.1016/j.celrep.2020.107675

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262601/
https://www.ncbi.nlm.nih.gov/pubmed/32460026
http://dx.doi.org/10.1016/j.celrep.2020.107675

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