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Microglia depletion fails to abrogate inflammation-induced sickness in mice and rats

BACKGROUND: Production of inflammatory mediators by reactive microglial cells in the brain is generally considered the primary mechanism underlying the development of symptoms of sickness in response to systemic inflammation. METHODS: Depletion of microglia was achieved in C57BL/6 mice by chronic or...

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Detalles Bibliográficos
Autores principales: Vichaya, Elisabeth G., Malik, Sajida, Sominsky, Luba, Ford, Bianca G., Spencer, Sarah J., Dantzer, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262755/
https://www.ncbi.nlm.nih.gov/pubmed/32475344
http://dx.doi.org/10.1186/s12974-020-01832-2