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Exon skipping of TGFβRI affects signalling and ECM expression in hypertrophic scar-derived fibroblasts

BACKGROUND: In burn patients, wound healing is often accompanied by hypertrophic scar (HS) development, resulting in both functional and aesthetic problems. HSs are characterised by abundant presence of myofibroblasts that contribute to overproduction of extracellular matrix (ECM) that is regulated...

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Detalles Bibliográficos
Autores principales: Raktoe, Rajiv S, Rietveld, Marion H, Out-Luiting, Jacoba J, Kruithof-de Julio, Marianna, van Zuijlen, Paul PM, van Doorn, Remco, Ghalbzouri, Abdoelwaheb El
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7263111/
https://www.ncbi.nlm.nih.gov/pubmed/32528734
http://dx.doi.org/10.1177/2059513120908857