TEX15 associates with MILI and silences transposable elements in male germ cells

DNA methylation is a major silencing mechanism of transposable elements (TEs). Here we report that TEX15, a testis-specific protein, is required for TE silencing. TEX15 is expressed in embryonic germ cells and functions during genome-wide epigenetic reprogramming. The Tex15 mutant exhibits DNA hypom...

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Detalles Bibliográficos
Autores principales: Yang, Fang, Lan, Yemin, Pandey, Radha Raman, Homolka, David, Berger, Shelley L., Pillai, Ramesh S., Bartolomei, Marisa S., Wang, P. Jeremy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2020
Materias:
Research Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7263141/
https://www.ncbi.nlm.nih.gov/pubmed/32381626
http://dx.doi.org/10.1101/gad.335489.119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7263141/
https://www.ncbi.nlm.nih.gov/pubmed/32381626
http://dx.doi.org/10.1101/gad.335489.119

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