Transcriptional down-regulation of metabolic genes by Gdown1 ablation induces quiescent cell re-entry into the cell cycle

Liver regeneration and metabolism are highly interconnected. Here, we show that hepatocyte-specific ablation of RNA polymerase II (Pol II)-associated Gdown1 leads to down-regulation of highly expressed genes involved in plasma protein synthesis and metabolism, a concomitant cell cycle re-entry assoc...

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Detalles Bibliográficos
Autores principales: Jishage, Miki, Ito, Keiichi, Chu, Chi-Shuen, Wang, Xiaoling, Yamaji, Masashi, Roeder, Robert G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7263145/
https://www.ncbi.nlm.nih.gov/pubmed/32381628
http://dx.doi.org/10.1101/gad.337683.120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7263145/
https://www.ncbi.nlm.nih.gov/pubmed/32381628
http://dx.doi.org/10.1101/gad.337683.120

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