4E-T-bound mRNAs are stored in a silenced and deadenylated form

Human 4E-T is an eIF4E-binding protein (4E-BP) present in processing (P)-bodies that represses translation and regulates decay of mRNAs destabilized by AU-rich elements and microRNAs (miRNAs). However, the underlying regulatory mechanisms are still unclear. Here, we show that upon mRNA binding 4E-T...

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Detalles Bibliográficos
Autores principales: Räsch, Felix, Weber, Ramona, Izaurralde, Elisa, Igreja, Cátia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7263148/
https://www.ncbi.nlm.nih.gov/pubmed/32354837
http://dx.doi.org/10.1101/gad.336073.119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7263148/
https://www.ncbi.nlm.nih.gov/pubmed/32354837
http://dx.doi.org/10.1101/gad.336073.119

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