Cargando…
BI6727, a polo-like kinase 1 inhibitor with promising efficacy on Burkitt lymphoma cells
OBJECTIVE: BI6727, an ATP-competitive PLK1 inhibitor, has been shown to cause cell death in multi-tumors. This study aimed to investigate the anti-tumor effect and potential molecular mechanism of BI6727 in human Burkitt lymphoma (BL) cell lines. METHODS: We assessed polo-like kinase 1 (PLK1) expres...
Autores principales: | Chen, Er, Pei, Renzhi |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7263168/ https://www.ncbi.nlm.nih.gov/pubmed/32468878 http://dx.doi.org/10.1177/0300060520926093 |
Ejemplares similares
-
BI-2536 and BI-6727, dual Polo-like kinase/bromodomain inhibitors, effectively reactivate latent HIV-1
por: Gohda, Jin, et al.
Publicado: (2018) -
A phase I study of two dosing schedules of volasertib (BI 6727), an intravenous polo-like kinase inhibitor, in patients with advanced solid malignancies
por: Lin, C-C, et al.
Publicado: (2014) -
Large-Scale Label-Free Comparative
Proteomics Analysis
of Polo-Like Kinase 1 Inhibition via the Small-Molecule Inhibitor
BI 6727 (Volasertib) in BRAF(V600E) Mutant Melanoma Cells
por: Cholewa, Brian D., et al.
Publicado: (2014) -
Eribulin alone or in combination with the PLK1 inhibitor BI 6727 triggers intrinsic apoptosis in Ewing sarcoma cell lines
por: WeiΔ, Lilly Magdalena, et al.
Publicado: (2017) -
Burkitt‐like lymphoma with 11q aberration
por: Collins, Katrina, et al.
Publicado: (2019)