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Screening for deafness-associated mitochondrial 12S rRNA mutations by using a multiplex allele-specific PCR method
Mitochondrial 12S rRNA A1555G and C1494T mutations are the major contributors to hearing loss. As patients with these mutations are sensitive to aminoglycosides, mutational screening for 12S rRNA is therefore recommended before the use of aminoglycosides. Most recently, we developed a novel multiple...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Portland Press Ltd.
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7263198/ https://www.ncbi.nlm.nih.gov/pubmed/32400865 http://dx.doi.org/10.1042/BSR20200778 |