Elevated ACE2 expression in the olfactory neuroepithelium: implications for anosmia and upper respiratory SARS-CoV-2 entry and replication

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The site of SARS-CoV-2 entry and replication critically impacts strategies for COVID-19 diagnosis, transmission mitigation, and treatment. We determined the cellular location of the SARS-CoV-2 target receptor protein, ACE2, in the human upper airway, finding striking enrichment (200–700 folds) in th...

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Detalles Bibliográficos
Autores principales: Chen, Mengfei, Shen, Wenjuan, Rowan, Nicholas R., Kulaga, Heather, Hillel, Alexander, Ramanathan, Murugappan, Lane, Andrew P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7263519/
https://www.ncbi.nlm.nih.gov/pubmed/32511390
http://dx.doi.org/10.1101/2020.05.08.084996

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7263519/
https://www.ncbi.nlm.nih.gov/pubmed/32511390
http://dx.doi.org/10.1101/2020.05.08.084996

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