Thrombopoietin is required for full phenotype expression in a JAK2(V617F) transgenic mouse model of polycythemia vera

The myeloproliferative neoplasms, polycythemia vera, essential thrombocytosis and primary myelofibrosis are hematopoietic stem cell disorders and share driver mutations that either directly activate the thrombopoietin receptor, MPL, or activate it indirectly through gain-of-function mutations in the...

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Detalles Bibliográficos
Autores principales: Spivak, Jerry L., Merchant, Akil, Williams, Donna M., Rogers, Ophelia, Zhao, Wanke, Duffield, Amy, Resar, Linda S., Moliterno, Alison R., Zhao, Zhizhuang J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7263591/
https://www.ncbi.nlm.nih.gov/pubmed/32479500
http://dx.doi.org/10.1371/journal.pone.0232801

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7263591/
https://www.ncbi.nlm.nih.gov/pubmed/32479500
http://dx.doi.org/10.1371/journal.pone.0232801

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