Enhanced phosphorylation of PERK in primary cultured neurons as an autonomous neuronal response to prion infection

Conversion of cellular prion protein (PrP(C)) into the pathogenic isoform of prion protein (PrP(Sc)) in neurons is one of the key pathophysiological events in prion diseases. However, the molecular mechanism of neurodegeneration in prion diseases has yet to be fully elucidated because of a lack of s...

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Detalles Bibliográficos
Autores principales: Tanaka, Misaki, Yamasaki, Takeshi, Hasebe, Rie, Suzuki, Akio, Horiuchi, Motohiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7263615/
https://www.ncbi.nlm.nih.gov/pubmed/32479530
http://dx.doi.org/10.1371/journal.pone.0234147

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7263615/
https://www.ncbi.nlm.nih.gov/pubmed/32479530
http://dx.doi.org/10.1371/journal.pone.0234147

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