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Enhanced phosphorylation of PERK in primary cultured neurons as an autonomous neuronal response to prion infection
Conversion of cellular prion protein (PrP(C)) into the pathogenic isoform of prion protein (PrP(Sc)) in neurons is one of the key pathophysiological events in prion diseases. However, the molecular mechanism of neurodegeneration in prion diseases has yet to be fully elucidated because of a lack of s...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7263615/ https://www.ncbi.nlm.nih.gov/pubmed/32479530 http://dx.doi.org/10.1371/journal.pone.0234147 |