Genetic Variants of the MGAT5 Gene Are Functionally Implicated in the Modulation of T Cells Glycosylation and Plasma IgG Glycome Composition in Ulcerative Colitis

The impact of genetic variants (single nucleotide polymorphisms [SNPs]) in the clinical heterogeneity of ulcerative colitis (UC) remains unclear. We showed that patients with UC exhibit a deficiency in MGAT5 glycogene transcription in intestinal T cells associated with a hyperimmune response. Herein...

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Detalles Bibliográficos
Autores principales: Pereira, Márcia S., Durães, Cecília, Catarino, Telmo A., Costa, José L., Cleynen, Isabelle, Novokmet, Mislav, Krištić, Jasminka, Štambuk, Jerko, Conceição-Neto, Nádia, Machado, José C., Marcos-Pinto, Ricardo, Magro, Fernando, Vermeire, Séverine, Lauc, Gordan, Lago, Paula, Pinho, Salomé S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7263653/
https://www.ncbi.nlm.nih.gov/pubmed/32352685
http://dx.doi.org/10.14309/ctg.0000000000000166

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7263653/
https://www.ncbi.nlm.nih.gov/pubmed/32352685
http://dx.doi.org/10.14309/ctg.0000000000000166

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