In Vivo Visual Screen for Dopaminergic Rab ↔ LRRK2-G2019S Interactions in Drosophila Discriminates Rab10 from Rab3

LRRK2 mutations cause Parkinson’s, but the molecular link from increased kinase activity to pathological neurodegeneration remains undetermined. Previous in vitro assays indicate that LRRK2 substrates include at least 8 Rab GTPases. We have now examined this hypothesis in vivo in a functional, elect...

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Detalles Bibliográficos
Autores principales: Petridi, Stavroula, Middleton, C. Adam, Ugbode, Chris, Fellgett, Alison, Covill, Laura, Elliott, Christopher J. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Genetics Society of America 2020
Materias:
Mutant Screen Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7263684/
https://www.ncbi.nlm.nih.gov/pubmed/32321836
http://dx.doi.org/10.1534/g3.120.401289

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7263684/
https://www.ncbi.nlm.nih.gov/pubmed/32321836
http://dx.doi.org/10.1534/g3.120.401289

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