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In Vivo Visual Screen for Dopaminergic Rab ↔ LRRK2-G2019S Interactions in Drosophila Discriminates Rab10 from Rab3
LRRK2 mutations cause Parkinson’s, but the molecular link from increased kinase activity to pathological neurodegeneration remains undetermined. Previous in vitro assays indicate that LRRK2 substrates include at least 8 Rab GTPases. We have now examined this hypothesis in vivo in a functional, elect...
Autores principales: | Petridi, Stavroula, Middleton, C. Adam, Ugbode, Chris, Fellgett, Alison, Covill, Laura, Elliott, Christopher J. H. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Genetics Society of America
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7263684/ https://www.ncbi.nlm.nih.gov/pubmed/32321836 http://dx.doi.org/10.1534/g3.120.401289 |
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