HIV-1 strains belonging to large phylogenetic clusters show accelerated escape from integrase inhibitors in cell culture compared with viral isolates from singleton/small clusters

Objectives: Viral phylogenetics revealed two patterns of HIV-1 spread among MSM in Quebec. While most HIV-1 strains (n = 2011) were associated with singleton/small clusters (cluster size 1–4), 30 viral lineages formed large networks (cluster size 20–140), contributing to 42% of diagnoses between 201...

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Detalles Bibliográficos
Autores principales: Brenner, Bluma G., Ibanescu, Ruxandra-Ilinca, Oliveira, Maureen, Roger, Michel, Hardy, Isabelle, Routy, Jean-Pierre, Kyeyune, Fred, Quiñones-Mateu, Miguel E., Wainberg, Mark A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7263826/
https://www.ncbi.nlm.nih.gov/pubmed/28472323
http://dx.doi.org/10.1093/jac/dkx118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7263826/
https://www.ncbi.nlm.nih.gov/pubmed/28472323
http://dx.doi.org/10.1093/jac/dkx118

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