Blockade of VLA4 sensitizes leukemic and myeloma tumor cells to CD3 redirection in the bone marrow microenvironment

Redirecting T cells to specifically kill malignant cells has been validated as an effective anti-cancer strategy in the clinic with the approval of blinatumomab for acute lymphoblastic leukemia. However, the immunosuppressive nature of the tumor microenvironment potentially poses a significant hurdl...

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Detalles Bibliográficos
Autores principales: Nair-Gupta, Priyanka, Rudnick, Stephen I., Luistro, Leopoldo, Smith, Melissa, McDaid, Ronan, Li, Yingzhe, Pillarisetti, Kodandaram, Joseph, Jocelin, Heidrich, Bradley, Packman, Kathryn, Attar, Ricardo, Gaudet, François
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7264144/
https://www.ncbi.nlm.nih.gov/pubmed/32483120
http://dx.doi.org/10.1038/s41408-020-0331-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7264144/
https://www.ncbi.nlm.nih.gov/pubmed/32483120
http://dx.doi.org/10.1038/s41408-020-0331-4

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