Cargando…

Targeting TRAF3IP2, Compared to Rab27, is More Effective in Suppressing the Development and Metastasis of Breast Cancer

Here we investigated the roles of Rab27a, a player in exosome release, and TRAF3IP2, an inflammatory mediator, in development and metastasis of breast cancer (BC) in vivo. Knockdown (KD) of Rab27a (MDA(KDRab27a)) or TRAF3IP2 (MDA(KDTRAF3IP2)) in triple negative MDA-MB231 cells reduced tumor growth b...

Descripción completa

Detalles Bibliográficos
Autores principales:	Alt, Eckhard U., Wörner, Philipp M., Pfnür, Andreas, Ochoa, Joana E., Schächtele, Deborah J., Barabadi, Zahra, Lang, Lea M., Srivastav, Sudesh, Burow, Matthew E., Chandrasekar, Bysani, Izadpanah, Reza
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7264196/ https://www.ncbi.nlm.nih.gov/pubmed/32483202 http://dx.doi.org/10.1038/s41598-020-64781-z

Ejemplares similares

TRAF3IP2, a novel therapeutic target in glioblastoma multiforme
por: Alt, Eckhard U., et al.
Publicado: (2018)

Targeting TRAF3IP2 inhibits angiogenesis in glioblastoma
por: Izadpanah, Amin, et al.
Publicado: (2022)

Dipeptidyl peptidase-4 (DPP-4) inhibition with linagliptin reduces western diet-induced myocardial TRAF3IP2 expression, inflammation and fibrosis in female mice
por: Aroor, Annayya R., et al.
Publicado: (2017)

lobChIP: from cells to sequencing ready ChIP libraries in a single day
por: Wallerman, Ola, et al.
Publicado: (2015)

Prognostic Significance of Rab27A and Rab27B Expression in Esophageal Squamous Cell Cancer
por: Yu, Fengqiang, et al.
Publicado: (2020)

Identification of human mutations in TRAF3IP1 in patients with nephronophthisis and retinal degeneration
por: Becker-Heck, A, et al.
Publicado: (2015)

TRAF6 triggers Mycobacterium-infected host autophagy through Rab7 ubiquitination
por: Ma, Qinmei, et al.
Publicado: (2023)

Common variants of ZNF750, RPTOR and TRAF3IP2 genes and psoriasis risk
por: Dębniak, T., et al.
Publicado: (2013)

Prognostic role of Rab27A and Rab27B expression in patients with non‐small cell lung carcinoma
por: Koh, Hyun Min, et al.
Publicado: (2018)

Inhibition of Rab27a and Rab27b Has Opposite Effects on the Regulation of Hair Cycle and Hair Growth
por: Ku, Kyung-Eun, et al.
Publicado: (2020)

TRAF3IP2–IL-17 Axis Strengthens the Gingival Defense against Pathogens
por: Zhang, J., et al.
Publicado: (2022)

Common variants at TRAF3IP2 are associated with susceptibility to psoriatic arthritis and psoriasis
por: Hüffmeier, Ulrike, et al.
Publicado: (2010)

T cell development involves TRAF3IP3-mediated ERK signaling in the Golgi
por: Zou, Qiang, et al.
Publicado: (2015)

Metabolic control of regulatory T cell stability and function by TRAF3IP3 at the lysosome
por: Yu, Xiaoyan, et al.
Publicado: (2018)

TRAF3IP3 promotes glioma progression through the ERK signaling pathway
por: Lin, Qi, et al.
Publicado: (2022)

Rab27 in tick extracellular vesicle biogenesis and infection
por: Rainer Butler, L., et al.
Publicado: (2023)

Functional implications of Rab27 GTPases in Cancer
por: Li, Zhihong, et al.
Publicado: (2018)

TRAF5 and TRAF3IP2 Gene Polymorphisms Are Associated with Behçet's Disease and Vogt-Koyanagi-Harada Syndrome: A Case-Control Study
por: Xiang, Qin, et al.
Publicado: (2014)

Rab27a Is Required for Human Cytomegalovirus Assembly
por: Fraile-Ramos, Alberto, et al.
Publicado: (2010)

NPR3 protects cardiomyocytes from apoptosis through inhibition of cytosolic BRCA1 and TNF-α
por: Lin, Dong, et al.
Publicado: (2016)

Knockdown of TRAF3IP2 suppresses the expression of VEGFA and the proliferation of keratinocytes and vascular endothelial cells
por: Song, Yali, et al.
Publicado: (2019)

TRAF3IP3 Is Cleaved by EV71 3C Protease and Exhibits Antiviral Activity
por: Li, Hui, et al.
Publicado: (2022)

Rab3GEP Is the Non-redundant Guanine Nucleotide Exchange Factor for Rab27a in Melanocytes
por: Figueiredo, Ana C., et al.
Publicado: (2008)

Molecular characterization of exosome-like vesicles from breast cancer cells
por: Kruger, Stefan, et al.
Publicado: (2014)

Rab27a Is Required for Regulated Secretion in Cytotoxic T Lymphocytes
por: Stinchcombe, Jane C., et al.
Publicado: (2001)

Rab27a Regulates the Peripheral Distribution of Melanosomes in Melanocytes
por: Hume, Alistair N., et al.
Publicado: (2001)

Rab27a builds a platform for HIV-1
por: Short, Ben
Publicado: (2015)

A role for Rab27 in neutrophil chemotaxis and lung recruitment
por: Singh, Rajesh K, et al.
Publicado: (2014)

Rab27a Contributes to the Processing of Inflammatory Pain in Mice
por: Gross, Tilman, et al.
Publicado: (2020)

Rab3A/Rab27A System Silencing Ameliorates High Glucose-Induced Injury in Podocytes
por: Martinez-Arroyo, Olga, et al.
Publicado: (2023)

Exophagy of annexin A2 via RAB11, RAB8A and RAB27A in IFN-γ-stimulated lung epithelial cells
por: Chen, Ying-Da, et al.
Publicado: (2017)

Identification of low-frequency TRAF3IP2 coding variants in psoriatic arthritis patients and functional characterization
por: Böhm, Beate, et al.
Publicado: (2012)

Novel germline TRAF3IP3 mutation in a dyad with familial acute B lymphoblastic leukemia
por: Pommert, Lauren, et al.
Publicado: (2021)

Rab27a Targeting to Melanosomes Requires Nucleotide Exchange but Not Effector Binding
por: Tarafder, Abul K, et al.
Publicado: (2011)

ChIP-seq in steatohepatitis and normal liver tissue identifies candidate disease mechanisms related to progression to cancer
por: Bysani, Madhusudhan, et al.
Publicado: (2013)

Rab27b Regulates Mast Cell Granule Dynamics and Secretion
por: Mizuno, Kouichi, et al.
Publicado: (2007)

Rab27a: A Key to Melanosome Transport in Human Melanocytes
por: Bahadoran, Philippe, et al.
Publicado: (2001)

High Rab27A expression indicates favorable prognosis in CRC
por: Shi, Chuanbing, et al.
Publicado: (2015)

RAB27A-mediated melanoma exosomes: promoters of invasion and metastasis
por: Guo, Dajiang, et al.
Publicado: (2019)

RAB27A promotes the proliferation and invasion of colorectal cancer cells
por: Li, Qingyan, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_cdd29ijgv1qnba53lq80e0124n