Role of DNA-LL37 complexes in the activation of plasmacytoid dendritic cells and monocytes in subjects with type 1 diabetes

Initiation of type 1 diabetes (T1D) is marked by the infiltration of plasmacytoid dendritic cells (pDCs) and monocytes in pancreatic islets. Dying beta cells release self-DNA, which forms complexes with antimicrobial peptide, LL37, and its delayed clearance can activate pDCs and monocytes. Here, we...

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Detalles Bibliográficos
Autores principales: Badal, Darshan, Dayal, Devi, Singh, Gunjan, Sachdeva, Naresh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7264208/
https://www.ncbi.nlm.nih.gov/pubmed/32483133
http://dx.doi.org/10.1038/s41598-020-65851-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7264208/
https://www.ncbi.nlm.nih.gov/pubmed/32483133
http://dx.doi.org/10.1038/s41598-020-65851-y

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