Defective NADPH production in mitochondrial disease complex I causes inflammation and cell death

Electron transport chain (ETC) defects occurring from mitochondrial disease mutations compromise ATP synthesis and render cells vulnerable to nutrient and oxidative stress conditions. This bioenergetic failure is thought to underlie pathologies associated with mitochondrial diseases. However, the pr...

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Detalles Bibliográficos
Autores principales: Balsa, Eduardo, Perry, Elizabeth A., Bennett, Christopher F., Jedrychowski, Mark, Gygi, Steven P., Doench, John G., Puigserver, Pere
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7264245/
https://www.ncbi.nlm.nih.gov/pubmed/32483148
http://dx.doi.org/10.1038/s41467-020-16423-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7264245/
https://www.ncbi.nlm.nih.gov/pubmed/32483148
http://dx.doi.org/10.1038/s41467-020-16423-1

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