Preparation of high drug-loading celastrol nanosuspensions and their anti-breast cancer activities in vitro and in vivo

As one of the main components of Tripterygium wilfordii Hook F, celastrol (CSL) has significant antitumor activity, but its clinical application has been limited by its poor solubility, low oral bioavailability and systemic toxicity. In this study, celastrol nanosuspensions (CSL-NSps) were prepared...

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Detalles Bibliográficos
Autores principales: Huang, Tiantian, Wang, Yian, Shen, Yiping, Ao, Hui, Guo, Yifei, Han, Meihua, Wang, Xiangtao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7264310/
https://www.ncbi.nlm.nih.gov/pubmed/32483248
http://dx.doi.org/10.1038/s41598-020-65773-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7264310/
https://www.ncbi.nlm.nih.gov/pubmed/32483248
http://dx.doi.org/10.1038/s41598-020-65773-9

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