A nanobody-based fluorescent reporter reveals human α-synuclein in the cell cytosol

Aggregation and spreading of α-Synuclein (αSyn) are hallmarks of several neurodegenerative diseases, thus monitoring human αSyn (hαSyn) in animal models or cell cultures is vital for the field. However, the detection of native hαSyn in such systems is challenging. We show that the nanobody NbSyn87,...

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Detalles Bibliográficos
Autores principales: Gerdes, Christoph, Waal, Natalia, Offner, Thomas, Fornasiero, Eugenio F., Wender, Nora, Verbarg, Hannes, Manzini, Ivan, Trenkwalder, Claudia, Mollenhauer, Brit, Strohäker, Timo, Zweckstetter, Markus, Becker, Stefan, Rizzoli, Silvio O., Basmanav, Fitnat Buket, Opazo, Felipe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7264335/
https://www.ncbi.nlm.nih.gov/pubmed/32483166
http://dx.doi.org/10.1038/s41467-020-16575-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7264335/
https://www.ncbi.nlm.nih.gov/pubmed/32483166
http://dx.doi.org/10.1038/s41467-020-16575-0

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