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A nanobody-based fluorescent reporter reveals human α-synuclein in the cell cytosol
Aggregation and spreading of α-Synuclein (αSyn) are hallmarks of several neurodegenerative diseases, thus monitoring human αSyn (hαSyn) in animal models or cell cultures is vital for the field. However, the detection of native hαSyn in such systems is challenging. We show that the nanobody NbSyn87,...
Autores principales: | Gerdes, Christoph, Waal, Natalia, Offner, Thomas, Fornasiero, Eugenio F., Wender, Nora, Verbarg, Hannes, Manzini, Ivan, Trenkwalder, Claudia, Mollenhauer, Brit, Strohäker, Timo, Zweckstetter, Markus, Becker, Stefan, Rizzoli, Silvio O., Basmanav, Fitnat Buket, Opazo, Felipe |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7264335/ https://www.ncbi.nlm.nih.gov/pubmed/32483166 http://dx.doi.org/10.1038/s41467-020-16575-0 |
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