Formation of ultralong DH regions through genomic rearrangement

BACKGROUND: Cow antibodies are very unusual in having exceptionally long CDR H3 regions. The genetic basis for this length largely derives from long heavy chain diversity (DH) regions, with a single “ultralong” DH, IGHD8–2, encoding over 50 amino acids. Many bovine IGHD regions have sequence similar...

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Detalles Bibliográficos
Autores principales: Smider, Brevin A., Smider, Vaughn V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265228/
https://www.ncbi.nlm.nih.gov/pubmed/32487018
http://dx.doi.org/10.1186/s12865-020-00359-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265228/
https://www.ncbi.nlm.nih.gov/pubmed/32487018
http://dx.doi.org/10.1186/s12865-020-00359-8

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