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Formation of ultralong DH regions through genomic rearrangement
BACKGROUND: Cow antibodies are very unusual in having exceptionally long CDR H3 regions. The genetic basis for this length largely derives from long heavy chain diversity (DH) regions, with a single “ultralong” DH, IGHD8–2, encoding over 50 amino acids. Many bovine IGHD regions have sequence similar...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265228/ https://www.ncbi.nlm.nih.gov/pubmed/32487018 http://dx.doi.org/10.1186/s12865-020-00359-8 |