FMRP(1–297)-tat restores ion channel and synaptic function in a model of Fragile X syndrome

Fragile X Syndrome results from a loss of Fragile X Mental Retardation Protein (FMRP). We now show that FMRP is a member of a Cav3-Kv4 ion channel complex that is known to regulate A-type potassium current in cerebellar granule cells to produce mossy fiber LTP. Mossy fiber LTP is absent in Fmr1 knoc...

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Detalles Bibliográficos
Autores principales: Zhan, Xiaoqin, Asmara, Hadhimulya, Cheng, Ning, Sahu, Giriraj, Sanchez, Eduardo, Zhang, Fang-Xiong, Zamponi, Gerald W., Rho, Jong M., Turner, Ray W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265297/
https://www.ncbi.nlm.nih.gov/pubmed/32488011
http://dx.doi.org/10.1038/s41467-020-16250-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265297/
https://www.ncbi.nlm.nih.gov/pubmed/32488011
http://dx.doi.org/10.1038/s41467-020-16250-4

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