Insights into catalysis and regulation of non-canonical ubiquitination and deubiquitination by bacterial deamidase effectors

The bacterial effector MavC catalyzes non-canonical ubiquitination of host E2 enzyme UBE2N without engaging any of the conventional ubiquitination machinery, thereby abolishing UBE2N’s function in forming K63-linked ubiquitin (Ub) chains and dampening NF-кB signaling. We now report the structures of...

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Detalles Bibliográficos
Autores principales: Wang, Yong, Zhan, Qi, Wang, Xinlu, Li, Peipei, Liu, Songqing, Gao, Guangxia, Gao, Pu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265302/
https://www.ncbi.nlm.nih.gov/pubmed/32488130
http://dx.doi.org/10.1038/s41467-020-16587-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265302/
https://www.ncbi.nlm.nih.gov/pubmed/32488130
http://dx.doi.org/10.1038/s41467-020-16587-w

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