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Insights into catalysis and regulation of non-canonical ubiquitination and deubiquitination by bacterial deamidase effectors
The bacterial effector MavC catalyzes non-canonical ubiquitination of host E2 enzyme UBE2N without engaging any of the conventional ubiquitination machinery, thereby abolishing UBE2N’s function in forming K63-linked ubiquitin (Ub) chains and dampening NF-кB signaling. We now report the structures of...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265302/ https://www.ncbi.nlm.nih.gov/pubmed/32488130 http://dx.doi.org/10.1038/s41467-020-16587-w |