TRPA1-dependent calcium transients and CGRP release in DRG neurons require extracellular calcium

Shang et al. (2016. J. Cell Biol. https://doi.org/10.1083/jcb.201603081) reported that activation of lysosomal TRPA1 channels led to intracellular calcium transients and CGRP release from DRG neurons. We argue that both findings are more likely due to influx of insufficiently buffered extracellular...

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Detalles Bibliográficos
Autores principales: Gebhardt, Lisa A., Kichko, Tetyana I., Fischer, Michael J.M., Reeh, Peter W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2020
Materias:
Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265312/
https://www.ncbi.nlm.nih.gov/pubmed/32434221
http://dx.doi.org/10.1083/jcb.201702151
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author Gebhardt, Lisa A.
Kichko, Tetyana I.
Fischer, Michael J.M.
Reeh, Peter W.
author_facet Gebhardt, Lisa A.
Kichko, Tetyana I.
Fischer, Michael J.M.
Reeh, Peter W.
author_sort Gebhardt, Lisa A.
collection PubMed
description Shang et al. (2016. J. Cell Biol. https://doi.org/10.1083/jcb.201603081) reported that activation of lysosomal TRPA1 channels led to intracellular calcium transients and CGRP release from DRG neurons. We argue that both findings are more likely due to influx of insufficiently buffered extracellular calcium rather than lysosomal release.
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spelling pubmed-72653122020-12-01 TRPA1-dependent calcium transients and CGRP release in DRG neurons require extracellular calcium Gebhardt, Lisa A. Kichko, Tetyana I. Fischer, Michael J.M. Reeh, Peter W. J Cell Biol Letter Shang et al. (2016. J. Cell Biol. https://doi.org/10.1083/jcb.201603081) reported that activation of lysosomal TRPA1 channels led to intracellular calcium transients and CGRP release from DRG neurons. We argue that both findings are more likely due to influx of insufficiently buffered extracellular calcium rather than lysosomal release. Rockefeller University Press 2020-05-20 /pmc/articles/PMC7265312/ /pubmed/32434221 http://dx.doi.org/10.1083/jcb.201702151 Text en © 2020 Gebhardt et al. http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Letter
Gebhardt, Lisa A.
Kichko, Tetyana I.
Fischer, Michael J.M.
Reeh, Peter W.
TRPA1-dependent calcium transients and CGRP release in DRG neurons require extracellular calcium
title TRPA1-dependent calcium transients and CGRP release in DRG neurons require extracellular calcium
title_full TRPA1-dependent calcium transients and CGRP release in DRG neurons require extracellular calcium
title_fullStr TRPA1-dependent calcium transients and CGRP release in DRG neurons require extracellular calcium
title_full_unstemmed TRPA1-dependent calcium transients and CGRP release in DRG neurons require extracellular calcium
title_short TRPA1-dependent calcium transients and CGRP release in DRG neurons require extracellular calcium
title_sort trpa1-dependent calcium transients and cgrp release in drg neurons require extracellular calcium
topic Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265312/
https://www.ncbi.nlm.nih.gov/pubmed/32434221
http://dx.doi.org/10.1083/jcb.201702151
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AT fischermichaeljm trpa1dependentcalciumtransientsandcgrpreleaseindrgneuronsrequireextracellularcalcium
AT reehpeterw trpa1dependentcalciumtransientsandcgrpreleaseindrgneuronsrequireextracellularcalcium

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