Mitochondrial translation, dynamics, and lysosomes combine to extend lifespan

In this issue, Liu et al. (2019. J. Cell. Biol. https://doi.org/10.1083/jcb.201907067) find that the inhibition of mitochondrial ribosomes in combination with impaired mitochondrial fission or fusion increases C. elegans lifespan by activating the transcription factor HLH-30, which promotes lysosoma...

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Detalles Bibliográficos
Autores principales: Ali, Levi, Haynes, Cole M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2020
Materias:
Spotlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265329/
https://www.ncbi.nlm.nih.gov/pubmed/32434220
http://dx.doi.org/10.1083/jcb.202005084
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author Ali, Levi
Haynes, Cole M.
author_facet Ali, Levi
Haynes, Cole M.
author_sort Ali, Levi
collection PubMed
description In this issue, Liu et al. (2019. J. Cell. Biol. https://doi.org/10.1083/jcb.201907067) find that the inhibition of mitochondrial ribosomes in combination with impaired mitochondrial fission or fusion increases C. elegans lifespan by activating the transcription factor HLH-30, which promotes lysosomal biogenesis.
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spelling pubmed-72653292020-12-01 Mitochondrial translation, dynamics, and lysosomes combine to extend lifespan Ali, Levi Haynes, Cole M. J Cell Biol Spotlight In this issue, Liu et al. (2019. J. Cell. Biol. https://doi.org/10.1083/jcb.201907067) find that the inhibition of mitochondrial ribosomes in combination with impaired mitochondrial fission or fusion increases C. elegans lifespan by activating the transcription factor HLH-30, which promotes lysosomal biogenesis. Rockefeller University Press 2020-05-20 /pmc/articles/PMC7265329/ /pubmed/32434220 http://dx.doi.org/10.1083/jcb.202005084 Text en © 2020 Ali and Haynes http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Spotlight
Ali, Levi
Haynes, Cole M.
Mitochondrial translation, dynamics, and lysosomes combine to extend lifespan
title Mitochondrial translation, dynamics, and lysosomes combine to extend lifespan
title_full Mitochondrial translation, dynamics, and lysosomes combine to extend lifespan
title_fullStr Mitochondrial translation, dynamics, and lysosomes combine to extend lifespan
title_full_unstemmed Mitochondrial translation, dynamics, and lysosomes combine to extend lifespan
title_short Mitochondrial translation, dynamics, and lysosomes combine to extend lifespan
title_sort mitochondrial translation, dynamics, and lysosomes combine to extend lifespan
topic Spotlight
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265329/
https://www.ncbi.nlm.nih.gov/pubmed/32434220
http://dx.doi.org/10.1083/jcb.202005084
work_keys_str_mv AT alilevi mitochondrialtranslationdynamicsandlysosomescombinetoextendlifespan
AT haynescolem mitochondrialtranslationdynamicsandlysosomescombinetoextendlifespan

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