Interleukin-6 derived from cancer-associated fibroblasts attenuates the p53 response to doxorubicin in prostate cancer cells

Cancer-associated fibroblasts (CAFs) promote tumor growth and progression, and increase drug resistance through several mechanisms. We have investigated the effect of CAFs on the p53 response to doxorubicin in prostate cancer cells. We show that CAFs produce interleukin-6 (IL-6), and that IL-6 atten...

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Detalles Bibliográficos
Autores principales: Cheteh, Emarndeena H., Sarne, Victoria, Ceder, Sophia, Bianchi, Julie, Augsten, Martin, Rundqvist, Helene, Egevad, Lars, Östman, Arne, Wiman, Klas G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265343/
https://www.ncbi.nlm.nih.gov/pubmed/32528731
http://dx.doi.org/10.1038/s41420-020-0272-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265343/
https://www.ncbi.nlm.nih.gov/pubmed/32528731
http://dx.doi.org/10.1038/s41420-020-0272-5

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