AGO-bound mature miRNAs are oligouridylated by TUTs and subsequently degraded by DIS3L2

MicroRNAs (miRNAs) associated with Argonaute proteins (AGOs) regulate gene expression in mammals. miRNA 3’ ends are subject to frequent sequence modifications, which have been proposed to affect miRNA stability. However, the underlying mechanism is not well understood. Here, by genetic and biochemic...

Descripción completa

Detalles Bibliográficos
Autores principales: Yang, Acong, Shao, Tie-Juan, Bofill-De Ros, Xavier, Lian, Chuanjiang, Villanueva, Patricia, Dai, Lisheng, Gu, Shuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265490/
https://www.ncbi.nlm.nih.gov/pubmed/32488030
http://dx.doi.org/10.1038/s41467-020-16533-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265490/
https://www.ncbi.nlm.nih.gov/pubmed/32488030
http://dx.doi.org/10.1038/s41467-020-16533-w

Ejemplares similares