The ABCG2 Q141K hyperuricemia and gout associated variant illuminates the physiology of human urate excretion

The pathophysiological nature of the common ABCG2 gout and hyperuricemia associated variant Q141K (rs2231142) remains undefined. Here, we use a human interventional cohort study (ACTRN12615001302549) to understand the physiological role of ABCG2 and find that participants with the Q141K ABCG2 varian...

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Detalles Bibliográficos
Autores principales: Hoque, Kazi Mirajul, Dixon, Eryn E., Lewis, Raychel M., Allan, Jordyn, Gamble, Gregory D., Phipps-Green, Amanda J., Halperin Kuhns, Victoria L., Horne, Anne M., Stamp, Lisa K., Merriman, Tony R., Dalbeth, Nicola, Woodward, Owen M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265540/
https://www.ncbi.nlm.nih.gov/pubmed/32488095
http://dx.doi.org/10.1038/s41467-020-16525-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265540/
https://www.ncbi.nlm.nih.gov/pubmed/32488095
http://dx.doi.org/10.1038/s41467-020-16525-w

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