Network Pharmacology and Experimental Evidence Reveal Dioscin Suppresses Proliferation, Invasion, and EMT via AKT/GSK3b/mTOR Signaling in Lung Adenocarcinoma

PURPOSE: Dioscin, a natural glycoside derived from many plants, has been proved to exert anti-cancer activity. Several studies have found that it reverses TGF-β1-induced epithelial–mesenchymal transition (EMT). Whether dioscin can reverse EMT by pathways other than TGF-β is still unknown. METHODS: W...

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Detalles Bibliográficos
Autores principales: Mao, Wenli, Yin, Heng, Chen, Wenya, Zhao, Tingxiu, Wu, Shaofeng, Jin, He, Du, Biaoyan, Tan, Yuhui, Zhang, Ren, He, Yanli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7266311/
https://www.ncbi.nlm.nih.gov/pubmed/32546976
http://dx.doi.org/10.2147/DDDT.S249651

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7266311/
https://www.ncbi.nlm.nih.gov/pubmed/32546976
http://dx.doi.org/10.2147/DDDT.S249651

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