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Cortical Damage Associated With Cognitive and Motor Impairment in Hereditary Spastic Paraplegia: Evidence of a Novel SPAST Mutation

To determine the cortical mechanism that underlies the cognitive impairment and motor disability in hereditary spastic paraplegia (HSP), nine HSP patients from a Chinese family were examined using clinical evaluation, cognitive screening, and genetic testing. Controls were matched healthy subjects....

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Detalles Bibliográficos
Autores principales: Lin, Jian-zhong, Zheng, Hong-hua, Ma, Qi-lin, Wang, Chen, Fan, Li-ping, Wu, Han-ming, Wang, Dan-ni, Zhang, Jia-xing, Zhan, Yi-hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7267220/
https://www.ncbi.nlm.nih.gov/pubmed/32536902
http://dx.doi.org/10.3389/fneur.2020.00399