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2DImpute: imputation in single-cell RNA-seq data from correlations in two dimensions

SUMMARY: We developed 2DImpute, an imputation method for correcting false zeros (known as dropouts) in single-cell RNA-sequencing (scRNA-seq) data. It features preventing excessive correction by predicting the false zeros and imputing their values by making use of the interrelationships between both...

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Detalles Bibliográficos
Autores principales: Zhu, Kaiyi, Anastassiou, Dimitris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7267828/
https://www.ncbi.nlm.nih.gov/pubmed/32108864
http://dx.doi.org/10.1093/bioinformatics/btaa148