Reversal of Epigenetic Silencing Allows Robust HIV-1 Replication in the Absence of Integrase Function

Integration of the proviral DNA intermediate into the host cell genome normally represents an essential step in the retroviral life cycle. While the reason(s) for this requirement remains unclear, it is known that unintegrated proviral DNA is epigenetically silenced. Here, we demonstrate that human...

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Detalles Bibliográficos
Autores principales: Irwan, Ishak D., Karnowski, Heather L., Bogerd, Hal P., Tsai, Kevin, Cullen, Bryan R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7267885/
https://www.ncbi.nlm.nih.gov/pubmed/32487757
http://dx.doi.org/10.1128/mBio.01038-20

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7267885/
https://www.ncbi.nlm.nih.gov/pubmed/32487757
http://dx.doi.org/10.1128/mBio.01038-20

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