Cargando…
Reversal of Epigenetic Silencing Allows Robust HIV-1 Replication in the Absence of Integrase Function
Integration of the proviral DNA intermediate into the host cell genome normally represents an essential step in the retroviral life cycle. While the reason(s) for this requirement remains unclear, it is known that unintegrated proviral DNA is epigenetically silenced. Here, we demonstrate that human...
| Autores principales: | , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Microbiology
2020
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7267885/ https://www.ncbi.nlm.nih.gov/pubmed/32487757 http://dx.doi.org/10.1128/mBio.01038-20 |