SHP2 mutations induce precocious gliogenesis of Noonan syndrome-derived iPSCs during neural development in vitro

BACKGROUND: Noonan syndrome (NS) is a developmental disorder caused by mutations of Src homology 2 domain-containing protein tyrosine phosphatase 2 (SHP2). Although NS patients have diverse neurological manifestations, the mechanisms underlying the involvement of SHP2 mutations in neurological dysfu...

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Detalles Bibliográficos
Autores principales: Ju, Younghee, Park, Jun Sung, Kim, Daejeong, Kim, Bumsoo, Lee, Jeong Ho, Nam, Yoonkey, Yoo, Han-Wook, Lee, Beom Hee, Han, Yong-Mahn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7268229/
https://www.ncbi.nlm.nih.gov/pubmed/32493428
http://dx.doi.org/10.1186/s13287-020-01709-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7268229/
https://www.ncbi.nlm.nih.gov/pubmed/32493428
http://dx.doi.org/10.1186/s13287-020-01709-4

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